شابلون:Addiction-related plasticity
| Form of neuroplasticity or behavioral plasticity |
مؤحکملندیریجی نؤوعو | منبعلر | |||||
|---|---|---|---|---|---|---|---|
| افیونی مادهلر | روانی موحریکلر | یۆکسک یاغلی و یا شکرلی یئیهجک | سکس | فیزیکی مشغلهلر (ایروبیک) |
اطراف مۆحیطین زنگینلشدیرمهسی | ||
| ΔFosB expression in nucleus accumbens D1-type MSNs |
↑ | ↑ | ↑ | ↑ | ↑ | ↑ | [۱] |
| Behavioral plasticity | |||||||
| Escalation of intake | بله | بله | بله | [۱] | |||
| Psychostimulant cross-sensitization |
بله | Not applicable | بله | بله | Attenuated | Attenuated | [۱] |
| Psychostimulant self-administration |
↑ | ↑ | ↓ | ↓ | ↓ | [۱] | |
| Psychostimulant conditioned place preference |
↑ | ↑ | ↓ | ↑ | ↓ | ↑ | [۱] |
| Reinstatement of drug-seeking behavior | ↑ | ↑ | ↓ | ↓ | [۱] | ||
| Neurochemical plasticity | |||||||
| CREB phosphorylation in the nucleus accumbens |
↓ | ↓ | ↓ | ↓ | ↓ | [۱] | |
| Sensitized دوپامین response in the nucleus accumbens |
یوخ | بله | یوخ | بله | [۱] | ||
| Altered striatal dopamine signaling | ↓DRD2, ↑DRD3 | ↑DRD1, ↓DRD2, ↑DRD3 | ↑DRD1, ↓DRD2, ↑DRD3 | ↑DRD2 | ↑DRD2 | [۱] | |
| Altered striatal opioid signaling | No change or ↑μ-opioid receptors |
↑μ-opioid receptors ↑κ-opioid receptors |
↑μ-opioid receptors | ↑μ-opioid receptors | No change | No change | [۱] |
| Changes in striatal opioid peptides | ↑dynorphin No change: enkephalin |
↑dynorphin | ↓enkephalin | ↑dynorphin | ↑dynorphin | [۱] | |
| Mesocorticolimbic synaptic plasticity | |||||||
| Number of dendrites in the nucleus accumbens | ↓ | ↑ | ↑ | [۱] | |||
| Dendritic spine density in the nucleus accumbens |
↓ | ↑ | ↑ | [۱] | |||
